Journal of Chromatography A 2014-10-24

A novel automated hydrophilic interaction liquid chromatography method using diode-array detector/electrospray ionization tandem mass spectrometry for analysis of sodium risedronate and related degradation products in pharmaceuticals

Tiziana Bertolini, Lorenza Vicentini, Silvia Boschetti, Paolo Andreatta, Rita Gatti

Index: J. Chromatogr. A. 1365 , 131-9, (2014)

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Abstract

• HPLC fused core technology to analyze SR and its degradation products. • Stress test studies on raw material, finished products and placebos. • No interference of the complex matrices (new pharmaceuticals) was observed. • The main degradation product (SR N-oxide) was characterized by HPLC-ESI-MS.

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