Preparation of guanine and diaminopurine from biuret. Part III.

Irene M Lagoja, Piet Herdewijn

Index: Chem. Biodivers. 4(4) , 818-22, (2007)

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Abstract

Because of their potential prebiotic origin and relative chemical stability, urea, biuret, formic acid, and glycine amide might have played a role in the assembly process of purine bases. In this paper, we describe a short reaction path to purine nucleobases from these acyclic precursors. The formation of different purines was verified by UV and NMR spectroscopy, as well as by mass spectrometry.