[Effect of hyperbaric oxygenation on N-acetyl-L-asparaginic acid metabolism in different cerebral areas].

T I Bondarenko

Index: Ukr. Biokhim. Zh. 52(5) , 564-8, (1980)

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Abstract

The content of N-acetyl-l-asparaginic acid, CoA, CoASAc and the N-acetylaspartate amunohydrolase activity was determined in cerebral areas of rats at the normal level and at different stages of oxygen poisoning. At the preconvulsive stage of the oxygen poisoning the content of N-acetyl-l-asparaginic acid decreases in cerebral hemispheres by 54, in the midbrain and diencephalon by 23, in the medulla oblongata--by 27, and in the cerebellum by 21%. The N-acetylaspartate aminohydrolase activity, vice versa, increases by 58, 62, 57 and 60%, respectively. The content of CoA and CoASAc is unchanged. At the convulsive stage of hyperoxia the content of N-acetyl-l-asparaginic acid in the cerebral hemispheres and cerebellum is unchanged in the midbrain and diencephalon increases by 21% and in the medulla oblongata-by 15%. The n-acetylaspartate aminohydrolase activity in he cerebral hemispheres, midbrain, diencephalon and medulla oblongata is unchanged, in the cerebellum it increases by 100%. The CoA content in the brain decreases by 20%, CoASAc-by 16%.