Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy

Sudhir K. Yadav, Biplab Adhikary, Sandip K. Bandyopadhyay, Subrata Chattopadhyay

Index: Biochim. Biophys. Acta 1830(6) , 3776-86, (2013)

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Abstract

Background The gastro-intestinal disorders, induced by the NSAIDs including indomethacin (IND) remain unresolved medical problems. Herein, we disclose allylpyrocatechol (APC) as a potential agent against IND-gastropathy and rationalize its action mechanistically.