Chemical Communications 2013-02-11

Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins.

Takumi Yamaguchi, Tsuyoshi Uno, Yoshinori Uekusa, Maho Yagi-Utsumi, Koichi Kato

Index: Chem. Commun. (Camb.) 49(12) , 1235-7, (2013)

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Abstract

We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.

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