Journal of Organic Chemistry 2003-02-07

Palladium-catalyzed amination of aryl bromides with hindered N-alkyl-substituted anilines using a palladium(I) tri-tert-butylphosphine bromide dimer.

Mahavir Prashad, Xiao Yin Mak, Yugang Liu, Oljan Repic

Index: J. Org. Chem. 68(3) , 1163-4, (2003)

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Abstract

An efficient palladium-catalyzed amination of aromatic bromides with hindered N-alkyl-substituted anilines is described, either using the combination of Pd(OAc)(2) and P(t-Bu)(3) or a palladium(I) tri-tert-butylphosphine bromide dimer, [Pd(mu-Br)(t-Bu(3)P)](2), a new, commercially available, and easily handled catalyst.