Journal of Pharmaceutical and Biomedical Analysis 2012-01-01

Quantitative analysis of atractylenolide I in rat plasma by LC–MS/MS method and its application to pharmacokinetic study

Yujuan Li, Yushi Zhang, Zhimin Wang, Jingjing Zhu, Yuan Tian, Bo Chen, Yujuan Li, Yushi Zhang, Zhimin Wang, Jingjing Zhu, Yuan Tian, Bo Chen, Yujuan Li, Yushi Zhang, Zhimin Wang, Jingjing Zhu, Yuan Tian, Bo Chen

Index: J. Pharm. Biomed. Anal. 58 , 172-176, (2012)

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Abstract

Highlights ► We develop an HPLC/MS method for quantification of atractylenolide I in rat plasma. ► Pharmacokinetics was performed in rats ingested with 20 g/kg Atractylodis extract. ► Atractylenolide I was found to be absorbed quickly within 1 h. ► The biological half-life and the elimination rate constant of atractylenolide I were 1.94 ± 0.27 h and 0.365 ± 0.06 h, respectively.

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