Retention enhancement by pre-test beta-endorphin and oxotremorine and its reversal by scopolamine.

Tom Sieprath, Tobias D J Corne, Marco Nooteboom, Charlotte Grootaert, Andreja Rajkovic, Benjamin Buysschaert, Joke Robijns, Jos L V Broers, Frans C S Ramaekers, Werner J H Koopman, Peter H G M Willems, Winnok H De Vos

Index: Behav. Neural Biol 50(3) , 251-4, (1988)

Full Text: HTML

Abstract

The pre-test administration of beta-endorphin (0.05 microgram/mouse), oxotremorine sesquifumarate (5.0 micrograms/mouse), or beta-endorphin plus oxotremorine enhanced retention test performance of a conditioned emotional response in mice. The effects were blocked by scopolamine. Scopolamine had no effect of its own. The data suggest that the retention enhancement caused by beta-endorphin may involve the secondary activation of cholinergic mechanisms.