Decrease in glucose oxidation in isolated brown fat cells from rats due to tropolone and dimethoxybenzene.

J W Rosenthal

Index: Gen. Pharmacol. 12(1) , 47-50, (1981)

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Abstract

1. 1. Glucose conversion to carbon dioxide in control and insulin treated brown fat cells is reduced in the presence of tropolone and dimethoxybenzene. 2. 2. The effects of ortho-, meta- and para-dimethoxybenzene are similar to each other; all are more potent than monomethoxybenzene. 3. 3. The reduction in glucose oxidation with tropolone plus trimethoxybenzene is greater than that due to colchicine or to either agent alone. 4. 4. Since the methoxybenzenes and tropolone resemble the “A” and “C” rings of colchicine, their ability to reduce glucose oxidation is discussed in relationship to both the structure of the colchicine molecule and its effects on glucose oxidation.