Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein.
X L Shen, M Nielsen, M R Witt, O Sterner, O Bergendorff, M Khayyal
Index: Zhongguo Yao Li Xue Bao 15(5) , 385-8, (1994)
Full Text: HTML
Abstract
Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.
Related Compounds
Related Articles:
[Studies on flavonoid constituents from herbs of Artemisia ordosica II].
2006-12-01
[Zhongguo Zhong Yao Za Zhi 31(23) , 1959-61, (2006)]
2005-09-01
[Zhongguo Zhong Yao Za Zhi 30(17) , 1335-8, (2005)]
[Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC].
2005-04-01
[Zhongguo Zhong Yao Za Zhi 30(8) , 591-4, (2005)]
1999-11-01
[J. Agric. Food Chem. 47(11) , 4579-82, (1999)]
2010-09-28
[Cancer Lett. 295(2) , 252-9, (2010)]