Phytotherapy Research 2009-08-01

Antihyperlipidemic compounds from the fruit of Piper longum L.

Zhuang Jin, Gereltu Borjihan, Ruiguo Zhao, Zhaorigetu Sun, Gerald B Hammond, Toshiyuki Uryu

Index: Phytother Res. 23(8) , 1194-6, (2009)

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Abstract

A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.Copyright 2009 John Wiley & Sons, Ltd.