Urinary excretion of cyclohexanediol, a metabolite of the solvent cyclohexanone, by infants in a special care unit.
G A Mills, V Walker
Index: Clin. Chem. 36(6) , 870-4, (1990)
Full Text: HTML
Abstract
Using gas chromatography-mass spectrometry, we investigated the urinary excretion of organic acids of 278 newborn babies in a special care unit to obtain reference data and monitor metabolism. In 101 of 584 urine samples analyzed, we found isomers of cyclohexanediol. trans-1,2-Cyclohexanediol was always most abundant, with small amounts of 1,3- and 1,4-cyclohexanediol and, sometimes, traces of cis-1,2-cyclohexanediol. Glucuronide conjugates were not detected. The probable source was the solvent cyclohexanone, which was found as a contaminant of intravenous dextrose and the parenteral feeding solution, and was also leached into the infusion fluids from the administration set. We recovered 0.89 mg (range 0.74-0.98 mg, n = 5) of cyclohexanone from 150 mL of dextrose pumped through the infusion apparatus over 24 h, the normal rate for a 1-kg premature baby. Although this is well below toxic doses reported for mature animals, more data are needed for the newborn, particularly preterm infants who have a decreased capacity for glucuronide conjugation.
Related Compounds
Related Articles:
1999-06-01
[Scand. J. Work. Environ. Health 25(3) , 233-7, (1999)]
2003-04-22
[Carbohydr. Res. 338(9) , 963-8, (2003)]
1999-03-01
[Int. Arch. Occup. Environ. Health 72(2) , 115-20, (1999)]
2001-06-01
[Appl. Microbiol. Biotechnol. 55(6) , 721-6, (2001)]
Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol.
2000-10-01
[Chem. Pharm. Bull. 48(10) , 1536-40, (2000)]