A novel and efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water.
Y Kita, H Nambu, N G Ramesh, G Anilkumar, M Matsugi
Index: Org. Lett. 3(8) , 1157-60, (2001)
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Abstract
[reaction: see text]. The combination of water-soluble radical initiator 2,2'-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier 1-ethylpiperidine hypophosphite (EPHP), and surfactant cetyltrimethylammonium bromide (CTAB) was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates.
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