Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.

N Blavet, F V DeFeudis

Index: Physiol. Behav. 29(5) , 901-4, (1982)

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Abstract

Sprague-Dawley rats were used to further characterize the anorexic action of orally-administered THIP, a GABA-analogue. The anorexic action of THIP (5 or 10 mg/kg) was antagonized by prior subcutaneous injection of bicuculline (1 mg/kg), but not by prior subcutaneous injection of bicuculline-methobromide (1.5 mg/kg), strychnine-SO4 (0.75 mg/kg), pentylenetetrazol (25 mg/kg), or picrotoxin (1 mg/kg). Orally-administered GABA (50-300 mg/kg), bicuculline (1-10 mg/kg) or picrotoxin (1-10 mg/kg) generally did not inhibit food intake. These results indicate that the anorexic action of THIP is mediated by central GABA-receptors.