British Journal of Pharmacology 1991-08-01

Potencies of antagonists indicate that 5-HT1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia.

G A Kennett, G Curzon

Index: Br. J. Pharmacol. 103(4) , 2016-20, (1991)

Full Text: HTML

Abstract

1. 1-3(Chlorophenyl)piperazine (mCPP) (5 mg kg-1, i.p.) inhibited 2 h food intake in rats previously deprived of food for one day. Ten 5-hydroxytryptamine (5-HT) antagonists given s.c. opposed this hypophagic response. Calculated ID50 values correlated significantly with reported affinities (r = 0.81, n = 10, P less than 0.01) for 5-HT1C but not for 5-HT2, 5-HT1A, 5-HT1B or 5-HT1D receptors. 2. ID50 values of the ten antagonists against 5-hydroxytryptophan (5-HTP) + carbidopa-induced head shakes (a 5-HT2-mediated response) correlated significantly (r = 0.81, n = 10, P less than 0.01) with their affinities for 5-HT2 but not for 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptors. 3. ID50 values for inhibition of hypophagia and head shakes did not correlate significantly with each other. 4. Ratios of ID50 values against hypophagia and 5-HT2-mediated head shakes gave indices of relative in vivo potencies independent of differences in drug metabolism and disposition. These ratios correlated highly significantly (r = 0.91, n = 10, P less than 0.001) with the ratios of the affinities of the drugs for 5-HT1C (but not for 5-HT1A, 5-HT1B or 5-HT1B or 5-HT1D receptors) and with their affinities for 5-HT2 receptors. These results strongly support the hypothesis that mediation of mCPP-induced hypophagia is by stimulation of 5-HT1C receptors and the mediation of 5-HTP-induced head twitches by 5-HT2 receptors.


Related Compounds

Related Articles:

N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.

2015-01-01

[J. Pharmacol. Exp. Ther. 352(1) , 156-65, (2015)]

Simultaneous Quantitation of 78 Drugs and Metabolites in Urine with a Dilute-And-Shoot LC-MS-MS Assay.

2015-06-01

[J. Anal. Toxicol. 39 , 335-46, (2015)]

1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain.

1989-03-01

[Biol. Psychiatry 25(5) , 569-75, (1989)]

Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS.

2008-01-01

[J. Anal. Toxicol. 32(6) , 444-50, (2008)]

In vitro efficacy of new antiprotozoals against Philasterides dicentrarchi (Ciliophora, Scuticociliatida).

2004-11-23

[Dis. Aquat. Organ. 62(1-2) , 97-102, (2004)]

More Articles...