Pathological laughter.

G L Zellers, M Frank, J Dougherty

Index: Ann. Emerg. Med. 19(3) , 327-9, (1990)

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Abstract

A man experienced one hour and 40 minutes of continual, inappropriate, uncontrollable laughter. The onset was preceded by a single-inhalation exposure to an insecticide of very low toxicity. The episode was terminated by a single dose of IV diazepam. A discussion of pathological laughter, including its proposed pathophysiology, differential diagnosis, clinical relevance, and management, is presented.