Chemical Communications 2005-09-07

Simple iron-amine catalysts for the cross-coupling of aryl Grignards with alkyl halides bearing beta-hydrogens.

Robin B Bedford, Duncan W Bruce, Robert M Frost, Michael Hird

Index: Chem. Commun. (Camb.) (33) , 4161-3, (2005)

Full Text: HTML

Abstract

Mixtures of iron(III) chloride and appropriate amine ligands are active catalysts for the coupling of aryl Grignard reagents with primary and secondary alkyl halide substrates bearing beta-hydrogens, under mild and simple reaction conditions.

Related Compounds

Related Articles:

Iron-catalyzed cross-coupling of alkyl halides with alkenyl grignard reagents.

2007-01-01

[Angew. Chem. Int. Ed. Engl. 46 , 6521, (2007)]

Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].

2004-03-11

[J. Med. Chem. 47 , 1400, (2004)]

Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core.

2004-01-19

[Bioorg. Med. Chem. Lett. 14 , 377, (2004)]

(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.

2004-04-19

[Bioorg. Med. Chem. Lett. 14 , 1991, (2004)]

More Articles...