[Teratogenic effect of the fungicide calixin].

A I Shtenberg, G N Zaeva, T Z Rysina, E V Gavrilenko

Index: Vopr. Pitan. (6) , 55-61, (1981)

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Abstract

Experimental studies on Wistar rats revealed that the fungicide calixin (N-tridecyl-2.6-dimethylmorpholine) has a teratogenic effect. This effect manifested in edemas, hemorrhages, hematomas, abnormal development of the brain (hydrocephalia), visceral cranium (micrognathia, cleft palate) and genitourinary system (hydronephrosis), in decreased size of pelvic bones, shoulder girdle, front and hind limbs, etc. Marked teratogenic effects was in good agreement with the dose. Threshold and subthreshold doses of calixin in terms of the teratogenic effect were 0.6 and 0.13 mg/kg, respectively. Calixin produces a clear-cut specific teratogenic effect that is evidenced by a wide spectrum of specific action (class I of extremely hazardous substances). The most pronounced changes were induced by calixin administration during the entire period of pregnancy (days 1-20) as compared to its administration during organogenesis (days 7-15).