Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.
Manal S Elmasry, Ian S Blagbrough, Michael G Rowan, Hanaa M Saleh, Afaf Aboul Kheir, Philip J Rogers
Index: J. Pharm. Biomed. Anal. 54(4) , 646-52, (2011)
Full Text: HTML
Abstract
An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines when stored, with other medications, in Venalink blister packs (monitored dosage system) for periods of up to 35 days. Chromatographic separation was achieved on a reversed-phase C(12) column with an isocratic mixture of methanol, water and acetic acid as the mobile phase. The method was validated regarding: accuracy, precision, detection limits, quantification limits, specificity and robustness.Copyright © 2010 Elsevier B.V. All rights reserved.
Related Compounds
Related Articles:
2013-01-01
[Pak. J. Pharm. Sci. 26(1) , 175-83, (2013)]
Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.
2011-08-01
[Pharm. Dev. Technol. 16(4) , 331-42, (2011)]
A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome.
2010-02-07
[World J. Gastroenterol. 16(5) , 547-53, (2010)]
2010-01-01
[J. AOAC Int. 93(4) , 1192-200, (2010)]
2010-11-01
[J. Fluoresc. 20(6) , 1275-85, (2010)]