Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides.

Achim Porzelle, Michael D Woodrow, Nicholas C O Tomkinson

Index: Org. Lett. 11 , 233, (2009)

Full Text: HTML

Abstract

The bis-pyrazole phosphine ligand BippyPhos is effective for the palladium-catalyzed cross-coupling of hydroxylamines with aryl bromides, chlorides, and iodides. Reactions proceed smoothly at 80 degrees C in toluene in the presence of Cs(2)CO(3) to give synthetically versatile N-arylhydroxylamine products in good to excellent yield.