Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.
René Holm, Janne Z Hesselkilde, Erling B Jørgensen, Anette Müllertz
Index: Eur. J. Pharm. Sci. 47(2) , 347-51, (2012)
Full Text: HTML
Abstract
The purpose of this study was to evaluate if a rat model, based upon co-administration of the anion-exchanging resin, cholestyramine, could replace surgery when evaluating the importance of bile on drug absorption. Two different formulations were used for the administration of halofantrine; polyethylene glycol 400 (PEG 400) and PEG 400/polysorbate 80 (50:50, w/w%), as a positive and negative control on the dependency of bile. No significant effect of the resin was detected after evaluation of three different pre-dosing regimes, but in line with previous studies the formulation containing polysorbate 80 showed a significant increase in the absorption of halofantrine. This study therefore demonstrates that the pre-dosing of rats with Cholestyramine can not replace surgical bile duct cannulation if a formulation needs to be evaluated for its bile dependency.Copyright © 2012 Elsevier B.V. All rights reserved.
Related Compounds
Related Articles:
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
2012-07-01
[Chirality 24(7) , 558-65, (2012)]
2012-03-01
[Antimicrob. Agents Chemother. 56(3) , 1382-9, (2012)]
2012-11-01
[J. Pharm. Pharmacol. 64(11) , 1603-13, (2012)]
CDA: combinatorial drug discovery using transcriptional response modules.
2012-01-01
[PLoS ONE 7(8) , e42573, (2012)]
2011-08-01
[Mol. Pharm. 8(4) , 1132-9, (2011)]