Journal of Organic Chemistry 2007-07-06

New catalysts for Suzuki-Miyaura coupling reactions of heteroatom-substituted heteroaryl chlorides.

Anil S Guram, Xiang Wang, Emilio E Bunel, Margaret M Faul, Robert D Larsen, Michael J Martinelli

Index: J. Org. Chem. 72 , 5104, (2007)

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Abstract

The new air-stable PdCl2[PR2(Ph-R')]2 complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids. The coupling reactions catalyzed by the new complexes exhibit high product yields (88-99%) and high catalyst turnover numbers (up to 10,000 TON).