Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin

Samantha J. McCavera, David M. Soderlund

Index: Neurotoxicology 33(3) , 384-90, (2012)

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Abstract

Highlights ► We constructed Nav1.6Q3 sodium channels containing the IFM/QQQ mutation. ► Nav1.6Q3 channels expressed in Xenopus oocytes exhibited persistent activation. ► Opening of Nav1.6Q3 channels enhanced modification by tefluthrin and deltamethrin. ► Modification by S-bioallethrin was not affected by channel opening. ► These results provide evidence for differential pyrethroid binding to open channels.