A rational approach to tuning the pKa values of rhodamines for living cell fluorescence imaging.

Lin Yuan, Weiying Lin, Yanming Feng

Index: Org. Biomol. Chem. 9 , 1723-1726, (2011)

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Abstract

A novel strategy to systematically tune the pK(a) values of rhodamines is described. This strategy was applied to rationally develop compound 1e with a pK(a) of 6.5, the highest among rhodamine amide derivatives, and it could be employed to detect acidic pH variations in living cells with a turn-on signal.