Chemical Communications 2015-10-21

Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins.

Lisa Fetter, Jonathan Richards, Jessica Daniel, Laura Roon, Teisha J Rowland, Andrew J Bonham

Index: Chem. Commun. (Camb.) 51(82) , 15137-40, (2015)

Full Text: HTML

Abstract

Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for ricin and botulinum neurotoxins, which display robust and specific signal at nanomolar concentrations and function in dilute serum. These biosensors may aid future efforts for the rapid diagnosis of toxins.

Related Compounds

Related Articles:

Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.

1988-11-15

[Cancer Res. 48 , 6396, (1988)]

Modification of the carbohydrate in ricin with metaperiodate-cyanoborohydride mixtures. Effects on toxicity and in vivo distribution.

1985-02-15

[Eur. J. Biochem. 147 , 197, (1985)]

Modification of the carbohydrate in ricin with metaperiodate and cyanoborohydride mixtures: effect on binding, uptake and toxicity to parenchymal and non-parenchymal cells of rat liver.

1985-09-27

[Biochim. Biophys. Acta 842 , 12, (1985)]

More Articles...