The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney.
J D Watkins, J Jarabak
Index: Prostaglandins 30(2) , 335-49, (1985)
Full Text: HTML
Abstract
Renal 9-ketoprostaglandin reductase activity from rabbits fed 0.3 g or 2.5 g NaCl per 100 g chow was measured in both centrifuged homogenates and in purified enzyme fractions. There was no salt related increase in 9-ketoprostaglandin reductase activity. PGA1-glutathione, 9, 10-phenanthrenequinone, and 4-nitrobenzaldehyde were better substrates for the purified 9-ketoprostaglandin reductases than was PGE2. Several carbonyl reductases were isolated which used PGA1-glutathione, 9, 10-phenanthrenequinone, and 4-nitrobenzaldehyde, but not PGE2, as substrates. Although PGA1-glutathione was a more faithful indicator of PGE2-related 9-ketoprostaglandin reductase activity than either 9, 10-phenanthrenequione or 4-nitrobenzaldehyde, it did not always provide an accurate estimate of that activity.
Related Compounds
Related Articles:
2015-06-01
[Free Radic. Biol. Med. 83 , 66-76, (2015)]
A novel synthesis of racemic and enantiomeric forms of prostaglandin B1 methyl ester.
2000-08-25
[J. Org. Chem. 65(17) , 5127-30, (2000)]
Prostaglandin B1 can modify the pressor responses to sympathetic nerve stimulation.
1983-09-01
[Res. Commun. Chem. Pathol. Pharmacol. 41(3) , 397-405, (1983)]
1982-02-21
[J. Theor. Biol. 94(4) , 943-9, (1982)]
The percutaneous penetration of prostaglandin E1 and its alkyl esters.
1999-04-19
[J. Control. Release 58(3) , 349-55, (1999)]