Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system.
S Krivobok, F Seigle-Murandi, R Steiman, D R Marzin, V Betina
Index: Mutat. Res. 279(1) , 1-8, (1992)
Full Text: HTML
Abstract
Unsubstituted anthraquinone, 4 substituted anthraquinones (emodin, danthron, physcion, a new compound M-108-C) and 3 dimers (skyrin, rugulosin, rugulin) were tested using the Ames/Salmonella assay (strains TA98, TA100, TA1537 and TA102). Danthron and emodin were found to be mutagenic for TA1537 with or without metabolic activation, physcion only with metabolic activation. A significant difference was found between the mutagenic activities of emodin (16.2 His+/nmole) and danthron (6.5 His+/nmole) as well as a high specific mutagenic activity for physcion (11.6 His+/nmole). These results on structure-mutagenic activity relationships suggest that the 6-methyl group plays an important role in the mutagenic activity after metabolic activation. Furthermore, and contrary to emodin, physcion exhibited a weak mutagenic activity for TA102, probably due to the formation of a different metabolite. Such information is necessary to evaluate the potential carcinogenic hazard of these compounds.
Related Compounds
Related Articles:
1995-11-01
[Curr. Genet. 28(6) , 580-4, (1995)]
Progress in the chemistry of organic natural products. The chemistry of mycotoxins.
2013-01-01
[Fortschr. Chem. Org. Naturst. 97 , v-xv, 1-300, (2013)]
[Chemical constituents from Hypericum perforatum].
2012-08-01
[Zhongguo Zhong Yao Za Zhi 37(16) , 2408-12, (2012)]
1984-02-01
[Toxicol. Lett. 20(2) , 155-60, (1984)]