Some effects of piperazine citrate on skeletal muscle and central nervous system.

G Onuaguluchi, W C Mezue

Index: Arch. Int. Pharmacodyn. Ther. 290(1) , 104-16, (1987)

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Abstract

In the frog rectus abdominis and rat phrenic nerve-diaphragm preparations, piperazine citrate was shown to have some neuromuscular blocking activity. In the rat, d-tubocurarine was 500 times more potent than piperazine. This neuromuscular blocking effect of piperazine may be responsible for the hypotonia it sometimes induces in man. High doses of piperazine increased, in mice, the sleeping time due to pentobarbitone, but decreased the threshold for convulsion due to leptazol and strychnine, thus explaining piperazine-induced somnolence and worsening of epileptic attacks in man.