Synthesis of new carbon-11 labeled cyclofenil derivatives for PET imaging of breast cancer estrogen receptors.
Mingzhang Gao, Min Wang, Bruce H Mock, Kathy D Miller, George W Sledge, Gary D Hutchins, Qi-Huang Zheng
Index: Appl. Radiat. Isot. 66(4) , 523-9, (2008)
Full Text: HTML
Abstract
Carbon-11 labeled cyclofenil derivatives, [(11)C]methyl-2-{4-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([(11)C]16a), [(11)C]methyl-4-[bis(4-hydroxyphenyl)methylene]cyclohexanecarboxylate ([(11)C]16b), [(11)C]methyl-2-{3-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([(11)C]18a), and [(11)C]methyl-3-[bis(4-hydroxyphenyl)methylene]cyclohexanecarboxylate ([(11)C]18b), have been synthesized as new potential PET agents for imaging breast cancer estrogen receptors. The target tracers were prepared by O-[(11)C]methylation of their corresponding precursors using [(11)C]CH(3)OTf and isolated by a simplified SPE purification procedure in 35-50% radiochemical yields decay corrected to EOB, 15-20 min overall synthesis time, and 74-111 GBq/micromol specific activity at EOS.
Related Compounds
Related Articles:
A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.
2012-01-01
[BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)]
2003-12-15
[Bioorg. Med. Chem. Lett. 13(24) , 4485-8, (2003)]
2007-05-01
[Nucl. Med. Biol. 34(4) , 383-90, (2007)]
1998-04-01
[J. Cell Sci. 111 ( Pt 7) , 951-65, (1998)]
1993-01-01
[Fertil. Steril. 59(1) , 125-9, (1993)]