Pharmazie 1984-10-01

Synthesis and determination of 10-oxomorphine, a decomposition product of morphine.

B Proksa

Index: Pharmazie 39(10) , 687-8, (1984)

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Abstract

10-Oxomorphine, a decomposition product of morphine, was synthesized from 6-O-acetylcodeine, which was oxidized with chromic acid to 6-O-acetyl-10-hydroxycodeine. This substance was then oxidized with manganese dioxide to 6-O-acetyl-10-oxocodeine, which on hydrolysis and O-demethylation gave 10-oxomorphine. UV-, fluorimetric spectrometry, TLC and HPLC methods were used for determination of 10-oxomorphine.