In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

Chinami Kuriyama, Ogusa Kamiyama, Kyoko Ikeda, Fujiko Sanae, Atsushi Kato, Isao Adachi, Tatsushi Imahori, Hiroki Takahata, Tadashi Okamoto, Naoki Asano, Chinami Kuriyama, Ogusa Kamiyama, Kyoko Ikeda, Fujiko Sanae, Atsushi Kato, Isao Adachi, Tatsushi Imahori, Hiroki Takahata, Tadashi Okamoto, Naoki Asano

Index: Bioorg. Chem. 16 , 7330-7336, (2008)

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Abstract

An amyio-1, 6-glucosidase inhibitor enhanced inhibition of hepatic glucose production in combination with glycogen phosphorylase inhibitor. The inhibitory activity of 1-deoxynojirimycin ( 1) toward human maltase was identical to that of voglibose ( 10) of an anti-diabetic agent. l-Isofagomine ( 8), a noncompetitive inhibitor of lysosomal β-glucosidase. also showed a chaperoning activity in N370S Gaucher fibroblasts.