Neuroreport 2006-01-23

Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.

Takahiro Yaguchi, Tetsu Nagata, Takeshi Mukasa, Hirokazu Fujikawa, Hideyuki Yamamoto, Satoshi Yamamoto, Hiroyuki Iso, Akito Tanaka, Tomoyuki Nishizaki

Index: Neuroreport 17 , 105-108, (2006)

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Abstract

In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the open-field test to assess motor activity, it was confirmed that the DCP-LA effect is not due to increased motor activity. In the passive avoidance test to assess fear memory, DCP-LA had no effect on the latency of acquisition and retention for SAMP8. The results of the present study, thus, suggest that DCP-LA could improve age-related learning impairment by enhancing cognitive functions.