Synthesis and biological activity of human inhibin-like peptide-(1-31).

D Yamashiro, C H Li, K Ramasharma, M R Sairam

Index: Proc. Natl. Acad. Sci. U. S. A. 81 , 5399, (1984)

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Abstract

A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the synthetic peptide was comparable to that of the natural product. It was also active in suppressing lutropin-releasing hormone-induced follitropin release in vivo in immature male rats.