Bioorganic & Medicinal Chemistry Letters 1998-03-03

Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.

N J Liverton, D J Armstrong, D A Claremon, D C Remy, J J Baldwin, R J Lynch, G Zhang, R J Gould

Index: Bioorg. Med. Chem. Lett. 8(5) , 483-6, (1998)

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Abstract

The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics.