Inorganic Chemistry
2007-04-16
Platinum complex as a nanomolar protein kinase inhibitor.
Douglas S Williams, Patrick J Carroll, Eric Meggers
Index: Inorg. Chem. 46 , 2944, (2007)
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Abstract
A pyridocarbazole platinum complex, which matches the overall shape of the natural product staurosporine, binds with high affinity at the adenosine triphosphate binding site of glycogen synthase kinase 3 (GSK-3alpha).
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