An air-stable palladium/N-heterocyclic carbene complex and its reactivity in aryl amination.
Mihai S Viciu, Rebecca M Kissling, Edwin D Stevens, Steven P Nolan
Index: Org. Lett. 4 , 2229, (2002)
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Abstract
[reaction: see text] The synthesis and characterization of [Pd(IPr)Cl(2)](2) (1), an air- and moisture-stable complex, is reported. The utilization of 1 as a catalyst for amination of aryl chlorides and bromides with a variety of amine coupling partners under mild conditions is described. The amination reactions with 1 show a remarkable insensitivity to oxygen and water, and thus the amination reactions could be performed in air on the benchtop with undried reagent grade solvents and substrates with small effects on reaction times and conversions.
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