Bioorganic & Medicinal Chemistry Letters 2001-08-20

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).

D A Heerding, G Chan, W E DeWolf, A P Fosberry, C A Janson, D D Jaworski, E McManus, W H Miller, T D Moore, D J Payne, X Qiu, S F Rittenhouse, C Slater-Radosti, W Smith, D T Takata, K S Vaidya, C C Yuan, W F Huffman

Index: Bioorg. Med. Chem. Lett. 11(16) , 2061-5, (2001)

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Abstract

1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.