Stereoselectivity of binding of α-(N-benzylamino)benzylphosphonic acids to prostatic acid phosphatase
Andriy I. Vovk, Iryna M. Mischenko, Vsevolod Yu. Tanchuk, Georgiy A. Kachkovskii, Sergiy Yu. Sheiko, Oleg I. Kolodyazhnyi, Valery P. Kukhar, Andriy I. Vovk, Iryna M. Mischenko, Vsevolod Yu. Tanchuk, Georgiy A. Kachkovskii, Sergiy Yu. Sheiko, Oleg I. Kolodyazhnyi, Valery P. Kukhar, Andriy I. Vovk, Iryna M. Mischenko, Vsevolod Yu. Tanchuk, Georgiy A. Kachkovskii, Sergiy Yu. Sheiko, Oleg I. Kolodyazhnyi, Valery P. Kukhar
Index: Bioorg. Med. Chem. Lett. 18(16) , 4620-3, (2008)
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Abstract
The evaluation of inhibitory activity of enantiomerically pure α-( N-benzylamino)benzylphosphonic acids toward human prostatic acid phosphatase is reported. The enantioselectivity has been explained using a molecular docking approach.
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