Organic Letters
2008-10-16
Palladium-catalyzed direct arylation of nitro-substituted aromatics with aryl halides.
Laurence Caron, Louis-Charles Campeau, Keith Fagnou
Index: Org. Lett. 10 , 4533, (2008)
Full Text: HTML
Abstract
Direct arylation reactions of nitrobenzenes and aryl halides occur in good yield and high ortho regioselectivity. These reactions can be performed on gram scale with as few as 3 equiv of the nitro arene relative to the aryl halide. The synthetic utility of this method is demonstrated via rapid synthesis of a Boscalid intermediate.
Related Compounds
Related Articles:
Catalytic intermolecular direct arylation of perfluorobenzenes.
2006-07-12
[J. Am. Chem. Soc. 128 , 8754, (2006)]
2008-07-17
[Org. Lett. 10 , 2923, (2008)]