Current Medicinal Chemistry 1999-03-01

Multi-component methodologies in solid-phase organic synthesis.

S L Dax, J J McNally, M A Youngman

Index: Curr. Med. Chem. 6(3) , 255, (1999)

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Abstract

Solid-phase organic synthesis, particularly when used in conjunction with combinatorial techniques, is emerging as a revolutionary technology in chemistry. Multi-component reaction systems are particularly valued because several elements of diversity can be introduced in a single transformation thereby expanding the diversity of compound libraries. A variety of multi-component reactions have been successfully adapted for solid-phase technology as described in this review.