Nuclear Medicine and Biology 2013-07-01

Synthesis and evaluation of11C-labeled naphthalene derivative as a novel non-peptidergic probe for the β-secretase (BACE1) imaging in Alzheimer's disease brain

Tomoki Kawai, Hidekazu Kawashima, Yuji Kuge, Hideo Saji

Index: Nucl. Med. Biol. 40(5) , 705-9, (2013)

Full Text: HTML

Abstract

Introduction As a first trial for in vivo imaging of β-secretase (BACE1) in Alzheimer's disease brain, we applied a novel non-peptidergic small molecule which has high affinity to the enzyme, naphthalene-1-carboxylic acid (3′-chloro-4′-fluoro-4-piperazin-1-yl-biphenyl-3-yl)amide (NCFB) into positron emission tomography (PET) probe. In the current study, N-11C-methylated compound of NCFB, [11C]Me-NCFB was synthesized and evaluated for the visualization of BACE1 in brain.


Related Compounds

Related Articles:

1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells.

2015-09-01

[Bioorg. Med. Chem. 23 , 5282-92, (2015)]

Dibenzazepines and dibenzoxazepines as sodium channel blockers.

2015-01-01

[Bioorg. Med. Chem. Lett. 25(1) , 43-7, (2015)]

Efficient nucleophilic aromatic substitution between aryl nitrofluorides and alkynes.

2007-07-05

[Org. Lett. 9(14) , 2741-3, (2007)]

Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.

2003-12-18

[J. Med. Chem. 46 , 5651-5662, (2003)]

More Articles...