Nucleosides, Nucleotides & Nucleic Acids 2010-03-01

Synthesis, spectral characterization, and biological activity of some new substituted 10H-phenothiazines, its ribofuranosides, and sulfones.

Naveen Gautam, Neha Ajmera, Shikha Gupta, D C Gautam

Index: Nucleosides Nucleotides Nucleic Acids 29(3) , 178-89, (2010)

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Abstract

This article describes the synthesis of new substituted 10 H-phenothiazines by Smiles rearrangement. These compounds are then used as a base to form ribofuranosides by treating them with a sugar (1-O-acetyl-2,3,5-tri-O-benzoyl-beta-ribofuranose). On oxidation with hydrogen peroxide in glacial acetic acid, these phenothiazines yield their sulfones. These compounds are screened for antioxidant and antimicrobial activity and their structure has been established by elemental analysis and spectroscopic data.