Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids.

Y Lapidot, S Rappoport, Y Wolman

Index: J. Lipid Res. 8 , 142-145, (1967)

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Abstract

Several crystalline N-hydroxysuccinimide esters of short- and long-chain fatty acids have been synthesized. These compounds react with free amino acids to form preferentially N-acylamino acids. The reaction of the N-hydroxysuccinimide esters with hydroxylamine and the behavior of the N-acylamino acids on thin-layer chromatography are described.