Highly practical and enantioselective cu-catalyzed conjugate addition of alkylzinc reagents to cyclic enones at ambient temperature.

Isaac J Krauss, James L Leighton

Index: Org. Lett. 5 , 3201, (2003)

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Abstract

[reaction: see text] A new ligand for Cu-catalyzed enantioselective additions of dialkylzincs to cyclic enones has been developed. In addition to providing good to excellent enantioselectivities with a range of cyclic enones and dialkylzincs, the ligand has several notworthy features: it can be readily prepared in just two steps, is an air-stable crystalline solid, and provides optimal performance at ambient temperature.