Fixed drug eruption from pamabrom.

S Nedorost, J S Taylor, C Camisa, K J Tomecki, T Helm, W J Durkin

Index: Cleve. Clin. J. Med. 58(1) , 33-4, (1991)

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Abstract

A young woman presented with recurrent skin lesions that were predominantly perioral. Fixed drug reaction was diagnosed based on her history of intermittent ingestion of Pamprin, a common menstrual symptom reliever, and characteristic erythematous, pigmented, edematous patches. After oral challenge with two of the three ingredients in Pamprin, a diagnosis of fixed drug reaction to pamabrom was made. Pamabrom is a mild diuretic present in several over-the-counter and prescription menstrual symptom relievers. This is the first reported case of fixed drug reaction to pamabrom.