Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR 1996-01-01

[Comparative study of the mechanism of inhibition of Sindbis virus reproduction by adamantane derivatives: remantadine and amide of 1-adamantane carboxylic acid].

V L Andronova

Index: Antibiot. Khimioter. 41(7-8) , 26-30, (1996)

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Abstract

Amide of 1-adamantane carboxylic acid (AACA), the same as remantadine, was shown to have no antiviral action and any influence on the efficiency of the Sindbis virus adsorption. However, it significantly inhibited the virus specific synthesis of RNA and protein. The main difference between AACA and remantadine was in the fact that the efficiency of the inhibition of the Sindbis virus reproduction and synthesis of the virus specific RNA in the presence of AACA did not markedly decrease even when AACA was added to the experimental system 7 hours after the adsorption whereas for the inhibitory effect of remantadine it was to be added to the system not later than 2 hours after the adsorption.