A versatile catalyst system for Suzuki-Miyaura syntheses of sterically hindered biaryls employing a cyclobutene-1,2-bis(imidazolium) salt.

Andreas Schmidt, Alireza Rahimi

Index: Chem. Commun. (Camb.) 46 , 2995-2997, (2010)

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Abstract

The catalyst system consisting of 3,3'-(3,4-bis(dichloro-methylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate), Pd(OAc)(2) and NaOtBu in toluene proved to be very effective for a broad variety of Suzuki-Miyaura reactions at room temperature. It is also suited for the synthesis of sterically hindered compounds including 2,6-di-tert-butyl-2'-substituted biaryls at elevated temperatures.