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sinomenine N-oxide

Names

[ CAS No. ]:
1000026-77-6

[ Name ]:
sinomenine N-oxide

[Synonym ]:
sinomenine-N-oxide

Biological Activity

[Description]:

Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Sinomenine N-oxide (10-200 μM, 2 h) 抑制 LPS 诱导的 Raw264.7 细胞中的 IL-6 和 TNF-α 水平[3]。

[References]

[1]. Liu WJ, et al. Network pharmacology approach to elucidate possible action mechanisms of Sinomenii Caulis for treating osteoporosis. J Ethnopharmacol. 2020 Jul 15;257:112871.  

[2]. Zeng HL, et al. New N-oxide alkaloids from the stems of Sinomenium acutum. Fitoterapia. 2023 Mar;165:105404.  

[3]. Li Q, et al. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sci. 2020 Nov 15;261:118433.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H23NO5

[ Molecular Weight ]:
345.39

[ Exact Mass ]:
345.15800

[ PSA ]:
85.19000

[ LogP ]:
1.98950

Related Compounds