Ipatasertib-NH2

Names

[ Name ]:
Ipatasertib-NH2

Biological Activity

[Description]:

Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

AKT[1]

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₆ClN₅O₂

[ Molecular Weight ]:
415.92

[ Storage condition ]:
-20°C

Ipatasertib-NH2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds