(Rac)-Golgicide A

Names

[ Name ]:
(Rac)-Golgicide A

[Synonym ]:
6,8-Difluoro-4-(3-pyridinyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c ]quinoline

Biological Activity

[Description]:

(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1[1].Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species[2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5(3):157-65.

[2]. van der Linden L, et al. Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. J Virol. 2010 Aug;84(15):7535-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄F₂N₂

[ Molecular Weight ]:
284.30

[ Exact Mass ]:
284.11300

[ PSA ]:
24.92000

[ LogP ]:
4.32430

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

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